Optimization of Quercetin Gel Formulation using Factorial Design Method and Antibacterial Test against Propionibacterium acnes

Quercetin is a flavonoid from group of polyphenolic compounds. can be used as an alternative to acne treatment, predominantly triggered by Propionibacterium acnes. This study aimed determine the effect and proportion carbopol 940, propylene glycol, glycerin on physical quality quercetin gel, ability optimum formula in antibacterial test, its diffusion using Franz diffusion. uses factorial design method for optimization. Optimization was carried out with parameters gel tested, including viscosity, dispersibility, antibacterial, The combination glycerin, glycol affected test significantly viscosity. In contrast, Franz's dispersion, properties. manufacture obtained concentration 940 0.5%, 15%, 10%. 22.20 mm, cumulative percent penetrated 97.91%.